| MERCEDES-BENZ S-CLASS (W222, V222, X222) S 320 (222.162) | 05.2014 - | 200kW / 272HP |
| MERCEDES-BENZ S-CLASS (W222, V222, X222) S 400 (222.165) | 2014-03 - 2017-05 | 245kW / 333HP |
| MERCEDES-BENZ S-CLASS (W222, V222, X222) S 400 Hybrid / h (222.057, 222.157) | 2013-05 - 2017-05 | 225kW / 306HP |
| MERCEDES-BENZ S-CLASS (W222, V222, X222) S 500 Hybrid / e (222.163) | 2014-07 - 2017-05 | 245kW / 333HP |
| MERCEDES-BENZ S-CLASS (W222, V222, X222) S 500 (222.082, 222.182) | 2013-05 - 2017-05 | 335kW / 455HP |
| MERCEDES-BENZ S-CLASS (W222, V222, X222) S 600 (222.176) | 2014-02 - | 390kW / 530HP |
| MERCEDES-BENZ S-CLASS (W222, V222, X222) S 63 AMG (222.077, 222.177) | 2013-05 - 2017-05 | 430kW / 585HP |
| MERCEDES-BENZ S-CLASS (W222, V222, X222) S 65 AMG (222.179) | 2014-02 - | 463kW / 630HP |
| MERCEDES-BENZ S-CLASS (W222, V222, X222) S 300 BlueTEC Hybrid / h (222.004, 222.104) | 2014-02 - 2017-05 | 150kW / 204HP |
| MERCEDES-BENZ S-CLASS (W222, V222, X222) S 300 BlueTEC Hybrid / h (222.104) | 2014-02 - 2017-05 | 170kW / 231HP |
| MERCEDES-BENZ S-CLASS (W222, V222, X222) S 350 BlueTEC / d (222.132, 222.032, 222.123) | 2013-05 - 2017-05 | 190kW / 258HP |
| MERCEDES-BENZ S-CLASS (W222, V222, X222) S 450 EQ Boost (222.158, 222.058) | 2017-07 - | 270kW / 367HP |
| MERCEDES-BENZ S-CLASS (W222, V222, X222) S 500 EQ Boost (222.060, 222.160) | 2017-07 - | 320kW / 435HP |
| MERCEDES-BENZ S-CLASS (W222, V222, X222) AMG S 63 (222.187) | 2017-05 - | 450kW / 612HP |
| MERCEDES-BENZ S-CLASS (W222, V222, X222) S 560 e (222.173) | 2018-10 - | 270kW / 367HP |
