| MERCEDES-BENZ S-CLASS (W222, V222, X222) S 320 (222.162) | 05.2014 - | 200kW / 272HP |
| MERCEDES-BENZ S-CLASS (W222, V222, X222) S 400 (222.165) | 2014-03 - 2017-05 | 245kW / 333HP |
| MERCEDES-BENZ S-CLASS (W222, V222, X222) S 400 4-matic (222.067, 222.167) | 2014-11 - 2017-05 | 245kW / 333HP |
| MERCEDES-BENZ S-CLASS (W222, V222, X222) S 400 Hybrid / h (222.057, 222.157) | 2013-05 - 2017-05 | 225kW / 306HP |
| MERCEDES-BENZ S-CLASS (W222, V222, X222) S 450 (222.066, 222.166) | 2017-02 - | 270kW / 367HP |
| MERCEDES-BENZ S-CLASS (W222, V222, X222) S 450 4-matic (222.064, 222.164, 222.964) | 2017-02 - | 270kW / 367HP |
| MERCEDES-BENZ S-CLASS (W222, V222, X222) S 450 EQ Boost (222.158, 222.058) | 2017-07 - | 270kW / 367HP |
| MERCEDES-BENZ S-CLASS (W222, V222, X222) S 450 EQ Boost 4-matic (222.059, 222.159) | 2017-07 - | 270kW / 367HP |
| MERCEDES-BENZ S-CLASS (W222, V222, X222) S 500 EQ Boost (222.060, 222.160) | 2017-07 - | 320kW / 435HP |
| MERCEDES-BENZ S-CLASS (W222, V222, X222) S 500 Hybrid / e (222.163) | 2014-07 - 2017-05 | 245kW / 333HP |
| MERCEDES-BENZ S-CLASS (W222, V222, X222) S 500 (222.082, 222.182) | 2013-05 - 2017-05 | 335kW / 455HP |
| MERCEDES-BENZ S-CLASS (W222, V222, X222) S 500 4-matic (222.085, 222.185) | 2013-05 - 2017-05 | 335kW / 455HP |
| MERCEDES-BENZ S-CLASS (W222, V222, X222) S 560 (222.083, 222.183) | 2017-07 - | 345kW / 469HP |
| MERCEDES-BENZ S-CLASS (W222, V222, X222) S 560 4-matic (222.086, 222.186) | 2017-05 - | 345kW / 469HP |
| MERCEDES-BENZ S-CLASS (W222, V222, X222) S 600 (222.176) | 2014-02 - | 390kW / 530HP |
| MERCEDES-BENZ S-CLASS (W222, V222, X222) S 63 AMG (222.077, 222.177) | 2013-05 - 2017-05 | 430kW / 585HP |
| MERCEDES-BENZ S-CLASS (W222, V222, X222) S 63 AMG 4-matic (222.178) | 2013-05 - 2017-05 | 430kW / 585HP |
| MERCEDES-BENZ S-CLASS (W222, V222, X222) S 65 AMG (222.179) | 2014-02 - | 463kW / 630HP |
| MERCEDES-BENZ S-CLASS (W222, V222, X222) AMG S 63 4-matic+ (222.188) | 2017-05 - | 450kW / 612HP |
| MERCEDES-BENZ S-CLASS (W222, V222, X222) S 300 BlueTEC Hybrid / h (222.004, 222.104) | 2014-02 - 2017-05 | 150kW / 204HP |
| MERCEDES-BENZ S-CLASS (W222, V222, X222) S 300 BlueTEC Hybrid / h (222.104) | 2014-02 - 2017-05 | 170kW / 231HP |
| MERCEDES-BENZ S-CLASS (W222, V222, X222) S 350 BlueTEC 4-matic (222.133) | 2014-02 - 2017-05 | 185kW / 252HP |
| MERCEDES-BENZ S-CLASS (W222, V222, X222) S 350 BlueTEC / d (222.132, 222.032, 222.123) | 2013-05 - 2017-05 | 190kW / 258HP |
| MERCEDES-BENZ S-CLASS (W222, V222, X222) S 350 BlueTEC / d 4-matic (222.033, 222.133) | 2014-02 - 2017-05 | 190kW / 258HP |
| MERCEDES-BENZ S-CLASS (W222, V222, X222) S 350 d (222.020, 222.120) | 2017-07 - | 210kW / 286HP |
| MERCEDES-BENZ S-CLASS (W222, V222, X222) S 350 d 4-matic (222.021, 222.121) | 2017-05 - | 210kW / 286HP |
| MERCEDES-BENZ S-CLASS (W222, V222, X222) S 400 d (222.034, 222.134) | 2017-07 - | 250kW / 340HP |
| MERCEDES-BENZ S-CLASS (W222, V222, X222) S 400 d 4-matic (222.035, 222.135) | 2017-05 - | 250kW / 340HP |
| MERCEDES-BENZ S-CLASS (W222, V222, X222) S 500 Maybach (222.982) | 2014-12 - 2017-05 | 335kW / 455HP |
| MERCEDES-BENZ S-CLASS (W222, V222, X222) S 500 Maybach 4-matic (222.985) | 2015-04 - 2017-05 | 335kW / 455HP |
| MERCEDES-BENZ S-CLASS (W222, V222, X222) S 560 Maybach (222.983) | 2017-07 - | 345kW / 469HP |
| MERCEDES-BENZ S-CLASS (W222, V222, X222) S 560 Maybach 4-matic (222.986) | 2017-07 - | 345kW / 469HP |
| MERCEDES-BENZ S-CLASS (W222, V222, X222) S 600 Maybach (222.976) | 2014-12 - 2018-11 | 390kW / 530HP |
| MERCEDES-BENZ S-CLASS (W222, V222, X222) S 650 Maybach (222.980) | 2017-07 - | 463kW / 630HP |